Antibiotics in acute bronchitis: a meta-analysis.

PurposeMost patients with acute bronchitis who seek medical care are treated with antibiotics, although the effectiveness of this intervention is uncertain. We performed a meta-analysis of randomized, controlled trials to estimate the effectiveness of antibiotics in the treatment of acute bronchitis.Subjects and methodsEnglish-language studies published January 1966 to April 1998 were retrieved using MEDLINE, bibliographies, and consultation with experts. Only randomized trials that enrolled otherwise healthy patients with a diagnosis of acute bronchitis, used an antibiotic in the treatment group and a placebo in the control group, and provided sufficient data to calculate an effect size were included.ResultsWe identified eight randomized controlled trials that satisfied all inclusion criteria. These studies used one of three antibiotics (erythromycin, doxycycline, trimethoprim/sulfamethoxazole). The use of antibiotics decreased the duration of cough and sputum production by approximately one-half day (summary effect size 0.21; 95% CI, 0.05 to 0.36). For specific symptoms, there were nonsignificant trends favoring the use of antibiotics: a decrease of 0.4 days of purulent sputum (95% CI, -0.1 to 0.8), a decrease of 0.5 days of cough (95% CI, -0.1 to 1.1), and a decrease of 0.3 days lost from work (95% CI, -0.6 to 1.1).ConclusionThis meta-analysis suggests a small benefit from the use of the antibiotics erythromycin, doxycycline, or trimethoprim/sulfamethoxazole in the treatment of acute bronchitis in otherwise healthy patients. As this small benefit must be weighed against the risk of side effects and the societal cost of increasing antibiotic resistance, we believe that the use of antibiotics is not justified in these patients

Fe-Ni Sulphides as Indicators of Alteration in CM Chondrites

This study looks at the sulphide abundance and composition of Fe-Ni sulphide grains in 12 CM chondrites to determine an alteration sequence for these chondrites

A study of the morphology, composition and mineral associations of Fe-Ni sulphides in CM carbonaceous chondrites

A study of the compositional and textural variations between Fe-Ni sulphides in a suite of pristine to extensively aqueously altered CM chondrites, using SEM and EMP techniques

A vision for the future of rural developmental venture capital

The era of recruiting smokestack industries and getting deep subsidies from the federal government to revitalize local economies is over. The economic future of struggling economies across the country will come from those communities themselves, based on local assets, local ideas, and driven by local entrepreneurs. To spark this growth, rural communities will need community development venture capital (CDVC) to help bring them back into the economic mainstream.Venture capital

Different degrees of aqueous alteration in sulphides within the CI1 chondrites

Sulphides in four different CI1 chondrites were analysed, to evaluate their composition, texture and morphology. The results reinforce the view that CI1 chondrites could be divided into two subgroups, based on their level of aqueous alteration

Fe-Ni Sulphides within a CM1 clast in Tagish Lake

The composition, abundance and mineral associations of Fe-Ni sulphides within a CM1 clast in Tagish Lake are described, and compared with Fe-Ni sulphides in the carbonate-rich and carbonate-poor lithology of Tagish Lake, as well as Fe-Ni sulphides from CI and CM chondrites

Fe isotopic composition of Martian meteorites

In the present work, we have measured iron isotope compositions of a group of Martian meteorites to establish a baseline Fe-isotope fractionation pattern in the case of high-temperature igneous rocks from Mars

Fe isotopic composition of Martian meteorites and some terrestrial analogues

We report Fe isotopic composition of seven martian meteorites and other terrestrial materials that may be considered Martian analogues

Isolated major aortopulmonary collateral as the sole pulmonary blood supply to an entire lung segment

Congenital systemic-to-pulmonary collateral arteries or major aortopulmonary collaterals are associated with cyanotic congenital heart disease with decreased pulmonary blood flow. Though it is usually associated with congenital heart diseases, there is an increased incidence of isolated acquired aortopulmonary collaterals in premature infants with chronic lung disease. Interestingly, isolated congenital aortopulmonary collaterals can occur without any lung disease, which may cause congestive heart failure and require closure. We present a neonate with an echocardiogram that showed only left-sided heart dilation. Further workup with a CT angiogram demonstrated an anomalous systemic artery from the descending thoracic aorta supplying the left lower lobe. He eventually developed heart failure symptoms and was taken to the catheterization laboratory for closure of the collateral. However, with the collateral being the only source of blood flow to the entire left lower lobe, he required surgical unifocalization. Isolated aortopulmonary collaterals without any other congenital heart disease or lung disease are rare. Our patient is the first reported case to have an isolated aortopulmonary collateral being the sole pulmonary blood supply to an entire lung segment. Due to its rarity, there is still much to learn about the origin and development of these collaterals that possibly developed prenatally